The variability of awareness may have important implications for the reliability of self-report of dysfunction across the AD spectrum. The current work identifies two patterns of self-awareness changes. First, older adults harboring amyloid have hypernosognosia, an increased awareness of their memory decline prior to measurable changes on objective measures. Second, MCI patients, in contrast, show a range of awareness from marked concern to the lack of insight about their memory ability.
Dr. McLaren has been involved in clinical imaging since 2002 and has work published in numerous high-profile journals including Science, The Journal of Neuroscience, Cerebral Cortex, Brain, NeuroImage, Neurology, and Human Brain Mapping.