Biospective Clinical Imaging Scientist, Donald McLaren, co-authors a Neuropsychologia article describing the relationship of memory self-awareness and amyloid pathology.

The variability of awareness may have important implications for the reliability of self-report of dysfunction across the AD spectrum. The current work identifies two patterns of self-awareness changes. First, older adults harboring amyloid have hypernosognosia, an increased awareness of their memory decline prior to measurable changes on objective measures. Second, MCI patients, in contrast, show a range of awareness from marked concern to the lack of insight about their memory ability.

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Dr. McLaren has been involved in clinical imaging since 2002 and has work published in numerous high-profile journals including Science, The Journal of Neuroscience, Cerebral Cortex, Brain, NeuroImage, Neurology, and Human Brain Mapping.

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Biospective Preclinical Scientist Elodie Brison presented a novel mouse model of α-synucleinopathy at the 13th International Conference on Alzheimer’s and Parkinson’s Diseases (ADPD) in Vienna, Austria.

This interesting inducible mouse model of α-synucleinopathy demonstrates olfactory dysfunction, as well as a reproducible pattern of spread of pathology through the olfactory network with a significant decrease in regional neuroanatomical volumes. This rapid, robust, inducible model can be used for preclinical studies to accelerate the development of disease-modifying treatments for PD and other synucleinopathies.

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Dr. Brison has been involved in preclinical sciences since 2014 and has work published in numerous high-profile journals and books including Journal of Virology, Journal of Neurovirology, Pathologie Biologie, Advances in Experimental Medicine and Biology, Revue Virologie, Neuroviral Infections: RNA viruses and Retroviruses, and Non-Flavivirus Encephalitis.

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Biospective Research Scientist, Jean-Philippe Coutu, authors a Neurobiology of Aging article linking two distinct and independent neurodegenerative patterns to clinical progression in MCI patients.

Understanding the neuropathological changes related to clinical progression is critical to developing novel therapeutics to address all aspects of Alzheimer’s disease. The present work illustrates the importance of white matter lesions and white matter atrophy on the cognitive decline in individuals with mild cognitive impairment. As part of a replicated factor analysis construct, these age- and vascular-related processes were demonstrated to be independent from other neurodegenerative processes like cortical atrophy that are more closely coupled to CSF tau biomarkers. The study shows that these age- and vascular-related processes have an effect similar if not greater than neurodegenerative processes on two-year longitudinal cognitive decline towards Alzheimer’s disease, as assessed with multiple clinical tests.

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Dr. Coutu has been involved in imaging since 2011 and has work published in numerous high-profile journals including Neurology, Neurobiology of Aging, The Journal of Alzheimers Disease, NeuroImage, and Journal of Cerebral Blood Flow and Metabolism.

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Biospective Clinical Imaging Scientist, Donald McLaren, co-authors a Neurology article defining resilience in asymptomic Alzheimer’s Disease.

Our ability to identify biomarker positive individuals with a high-risk of cognitive decline is critical to enriching clinical trial samples. The current work identifies a robust AD resilience phenotype. Results revealed levels of AD resilience were significantly correlated with annual change in memory performance. Thus, the AD resilience phenotype can: (1) identify those at high-risk for cognitive decline; and (2) provide a foundation from which the molecular basis can be explored.

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Dr. McLaren has been involved in clinical imaging since 2002 and has work published in numerous high-profile journals including Science, The Journal of Neuroscience, Cerebral Cortex, Brain, NeuroImage, and Human Brain Mapping.

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Meet with Biospective in December at the 2016 CTAD conference!

Biospective will be attending the 2016 CTAD (Clinical Trials in Alzheimer’s Disease Conference), December 8-10, in San Diego, CA.

Come and meet us at our poster presentation (P1-30) on Thursday, December 8: “Uncovering the Relationship Between β-Amyloid and Glucose Metabolism“.

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Biospective Chief Technology Officer, Alex Zijdenbos, co-authors a Frontiers in Neuroinformatics article discussing the flexibility and applicability of the MINC 2.0 file format for large, multi-modal data sets.

Dr. Zijdenbos has been involved in the development of the MINC imaging file format since 1994. MINC is an extensible, scale-able, self-documenting representation of neuroscientific imaging data with arbitrary orientation and dimensionality that is ideal for use in large scale imaging studies and databases.

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Meet with Biospective next week at the 4th World Parkinson Congress!

Biospective will be attending the 4th World Parkinson Congress, September 20-23, Portland, Oregon.

Come and meet us at our poster (P06.05) presentations on Thursday from 5:15 PM to 6:45 PM and on Friday from 11:30 AM to 1:30 PM, in Exhibit Hall B, Level 1: “Assessment of olfactory dysfunction in an inducible mouse model of α-synucleinopathy via multi-modality imaging“.

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Meet with Biospective in September at the 4th World Parkinson Congress!

Biospective will be attending the 4th World Parkinson Congress, September 20-23, Portland, Oregon.

Come and meet us at our poster presentation on Friday, September 23 (P06.05) in Exhibit Hall B, Level 1, from 11:30 AM to 1:30 PM: “Assessment of olfactory dysfunction in an inducible mouse model of α-synucleinopathy via multi-modality imaging“.

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The poster Biospective presented at AAIC 2016 is now online!

Uncovering the Relationship between Metabolism and β-amyloid in Mild Cognitive Impairment. Biospective’s latest analysis of ADNI data showing that distributed beta-amyloid load is related to glucose hypometabolism in individuals with MCI was well-received by scientists at the Alzheimer’s Association International Conference (AAIC) in Toronto.  The results demonstrate the importance of using multivariate statistical approaches to understanding the pathological and physiological changes in Alzheimer’s disease.

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Our Alpha-Synuclein and Tau Spreading Rodent Models are now available!

Biospective announces its new, leading-edge AD & PD rodent models:

Biospective Alpha-Synuclein Rodent Models
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Biospective Tau Spreading Rodent Models
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