PERMITS™

Parametric Ex-vivo Robust Molecular Imaging using Tissue Sections

Biospective's Fully-Automated Quantitative IHC Analysis Technology

PERMITS™ allows for rapid evaluation of protein expression to follow the natural evolution of pathology or response to therapeutic intervention. With PERMITS™, an efficacy study is reduced to simple comparisons of quantiative maps from different (control vs. treatment) study groups.  Biospective’s unique ability to generate population-specific 3D PERMITS™ average brain volumes allows for simple comparisons and highly-powered statistical analysis between different groups.

Advantages of Fully-Automated vs. Manual IHC Quantification

High-throughput analysis for large-scale studies

Analysis of multiple neuroanatomical structures

No intra-/inter-rater variability or bias

Tight correlation with in vivo MRI and PET imaging data



 3D PERMITS™ maps of β-amyloid burden superimposed on an in vivo mouse brain MRI scan

PERMITS™ allows for objective and multi-parametric
quantitative evaluaton of novel diagnostic and therapeutic agents