We have an active internal R&D program and on-going collaborations with researchers around the world. We continually present our work at international scientific conferences and regularly publish our work in high-impact, peer-reviewed journals.

Publications from members of our scientific team include:


Technology

  • Tohka J, Zijdenbos A, Evans A. Fast and robust parameter estimation for statistical partial volume models in brain MRI. Neuroimage 2004;23(1):84-97.
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  • MacDonald D, Kabani N, Avis D, Evans AC. Automated 3-D extraction of inner and outer surfaces of cerebral cortex from MRI. Neuroimage 2000;12(3):340-356.
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  • Sled JG, Zijdenbos AP, Evans AC. A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 1998;17(1):87-97.
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Rodent Models

  • Brisebois M, Zehntner SP, Estrada J, Owens T, Fournier S. A pathogenic role for CD8+ T cells in a spontaneous model of demyelinating disease. J Immunol 2006;177(4):2403-2411.
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  • Kuhlmann T, Remington L, Cognet I, Bourbonniere L, Zehntner S, Guilhot F, Herman A, Guay-Giroux A, Antel JP, Owens T, Gauchat JF. Continued administration of ciliary neurotrophic factor protects mice from inflammatory pathology in experimental autoimmune encephalomyelitis. Am J Pathol 2006;169(2):584-598.
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  • Zehntner SP, Brickman C, Bourbonnière L, Remington L, Caruso M, Owens T. Neutrophils that infiltrate the central nervous system regulate T cell responses. J Immunol 2005;174(8):5124-5131.
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Animal Imaging

  • Lau JC, Lerch JP, Sled JG, Henkelman RM, Evans AC, Bedell BJ. Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer’s disease. Neuroimage 2008;42(1):19-27.
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  • Grand’Maison M, Zehntner SP, Ho M-K, Hébert F, Wood A, Carbonell F, Zijdenbos AP, Bedell BJ. 3D ex vivo amyloid imaging and the relationship with MRI-derived measures of cortical thickness in an Alzheimer’s disease mouse model. Human Amyloid Imaging Conference 2013, Miami, FL, USA.
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  • Grand’Maison M, Hébert F, Ho M-K, Bedell BJ. MR imaging of arterial dysfunction in a transgenic mouse model of Alzheimer’s disease. Alzheimer’s Association International Conference 2012, Vancouver, BC, Canada
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Human Imaging & Clinical Trials

  • Khundrakpam BS, Reid A, Brauer J, Carbonell F, Lewis J, Ameis S, Karama S, Lee J, Chen Z, Das S, Evans AC. Developmental changes in organization of structural brain networks. Cereb Cortex 2013;23(9):2072-2085.
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  • He Y, Dagher A, Chen Z, Charil A, Zijdenbos A, Worsley K, Evans A. Impaired small-world efficiency in structural cortical networks in multiple sclerosis associated with white matter lesion load. Brain 2009;132(Pt 12):3366-3379.
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  • Lerch JP, Pruessner J, Zijdenbos AP, Collins DL, Teipel SJ, Hampel H, Evans AC. Automated cortical thickness measurements from MRI can accurately separate Alzheimer’s patients from normal elderly controls. Neurobiol Aging 2008;29(1):23-30.
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  • Charil A, Carbonell F, Zijdenbos AP, Evans AC, Bedell BJ. Amyloid-associated alterations in metabolic connectivity patterns in ADNI participants, Alzheimer and Dementia 2013;9(4), Supplement, P418-P419.
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  • Carbonell F, Charil A, Reid A, Zijdenbos AP, Evans AC, Bedell BJ. Functional network analysis of florbetapir-low and florbetapir-high ADNI MCI subjects, Alzheimer and Dementia 2012;8(4), Supplement, S17.
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Histology & IHC

  • Choi SR, Schneider JA, Bennett DA, Beach TG, Bedell BJ, Zehntner SP, Krautkramer MJ, Kung HF, Skovronsky DM, Hefti F, Clark CM. Correlation of amyloid PET ligand florbetapir F 18 binding with Aβ aggregation and neuritic plaque deposition in postmortem brain tissue. Alzheimer Dis Assoc Disord 2012;26(1):8-16.
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  • Clark CM, Pontecorvo MJ, Beach TG, Bedell BJ, Coleman RE, Doraiswamy PM, Fleisher AS, Reiman EM, Sabbagh MN, Sadowsky CH, Schneider JA, Arora A, Carpenter AP, Flitter ML, Joshi AD, Krautkramer MJ, Lu M, Mintun MA, Skovronsky DM. Cerebral PET with florbetapir compared with neuropathology at autopsy for detection of neuritic amyloid-β plaques: a prospective cohort study. Lancet Neurol 2012;11(8):669-678.
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  • Clark CM, Schneider JA, Bedell BJ, Beach TG, Bilker WB, Mintun MA, Pontecorvo MJ, Hefti F, Carpenter AP, Flitter ML, Krautkramer MJ, Kung HF, Coleman RE, Doraiswamy PM, Fleisher AS, Sabbagh MN, Sadowsky CH, Reiman EP, Reiman PEM, Zehntner SP, Skovronsky DM. Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA 2011;305(3):275-283.
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  • Ho M-K, Zijdenbos ZP, Zehntner SP, Hébert F, Grand’Maison M, Bedell BJ. Distinct cortical laminar patterns of amyloid deposition and astrogliosis in a mouse model of Alzheimer’s disease. Alzheimer’s & Parkinson’s Diseases Congress 2013, Florence, Italy.
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Contact Biospective

Our scientific team is always available to discuss our research activities. Please do not hesitate to contact us.

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