Biospective has substantial experience working with a large range of rodent models, particularly models of CNS diseases. We can utilize in-house, third-party, or client-supplied mouse and rat models for your studies. We are a one-stop shop providing a full range of preclinical services, including model generation, housing, dosing, imaging, behavioral testing, and pathology studies.


Our CNS models

  • Alzheimer’s Disease and Tauopathies

  • Mutant APP transgenic and knock-in mice
  • Tau transgenic and knock-in mice
  • Inducible tau mouse model

Download our Alzheimer’s Disease models brochure

  • Parkinson’s Disease and Synucleinopathies

  • Alpha-synuclein transgenic mice
  • Inducible alpha-synuclein model

Download our Parkinson’s Disease models brochure

  • Oncology

  • Mouse & rat glioma
  • Multiple Sclerosis

  • Cytokine-induced focal forebrain lesion (inflammation and demyelination) mouse model
  • Cuprizone mouse model
  • EAE mouse models


Drug Dosing Studies & Behavioral Testing

Our team has many years of experience performing dosing of experimental therapeutic agents via various routes

  • Intravenous (i.v.)
  • Intraperitoneal (i.p.)
  • Intramuscular (i.m.)
  • Per os (p.o.)
  • Subcutaneous (s.c.)
  • Intracranial

Biospective can perform a diversity of behavioral tests to complement our animal imaging and histology/IHC services

  • Fear & Anxiety
  • Learning & Memory
  • Motor function
  • Reward sensitivity

Posters & Publications

Zehntner SP, Zijdenbos AP, Bedell BJ, Cadavid D. Registration of DTI and MTR MRI data to quantitative Immunohistochemistry in a novel mouse model of inflammatory cerebral demyelination. Annual Meeting of the American Academy of Neurology 2013, San Diego, CA, USA.
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Miron VE, Zehntner SP, Kuhlmann T, Ludwin SK, Owens T, Kennedy TE, Bedell BJ, Antel JP. Statin therapy inhibits remyelination in the central nervous system. Am J Pathol 2009;174(5):1880-1890
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Remington LT, Babcock AA, Zehntner SP, Owens T. Microglial recruitment, activation, and proliferation in response to primary demyelination. Am J Pathol 2007;170(5):1713-1724.
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Contact Biospective

Our experts are always available to work with you on your custom animal model needs. Please do not hesitate to contact our preclinical team to discuss your study.

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