Biospective has developed a suite of advanced tools for fully-automated processing of images from multiple modalities, including human and animal MRI, PET, and digital microscopy. These sophisticated software packages provide quantitative, objective measures for research studies or preclinical/clinical drug trials. High-level quality control (QC) processes are built into all of our software applications.



PIANO™ is our industry-leading image processing platform for human brain MRI and PET studies. This 21 CFR Part 11 compliant, validated software includes core modules for structural MRI, BOLD fMRI, ASL MRI, DTI, amyloid PET, and FDG PET. The comprehensive, advanced, multi-modality capabilities of PIANO™ are unparalleled.

For academic researchers, Biospective provides privileged access to some of our PIANO™ modules (including Amyloid PET) through a Web-based portal. Please contact us for additional information.



NIGHTWING™ is Biospective’s state-of-the-art image processing software for animal brain MRI studies. NIGHTWING™ parallels the broad range of capabilities of PIANO™ and provides sensitive, quantitative measures for translational studies.

NIGHTWING™ is far more sophisticated than any other software solutions available for animal MRI studies.



Our proprietary, automated PERMITS™ software has been developed over many years to provide accurate quantification of immunohistochemistry data from digitized tissue sections. Using 2D PERMITS™, we can analyze individual sections from a broad range of tissues, such as brain, lung, and tumor.

For correlation of in vivo imaging and post-mortem histology/IHC data from mouse or rat brain, we have developed 3D PERMITS™, which includes accurate 3D reconstruction of brain tissue sections. The powerful combination of NIGHTWING™ and PERMITS™ allows for comprehensive phenotyping or preclinical therapeutic efficacy studies.

Posters & Publications

Charil A, Dagher A, Lerch JP, Zijdenbos AP, Worsley KJ, Evans AC. Focal cortical atrophy in multiple sclerosis: relation to lesion load and disability. Neuroimage 2007;34(2):509-517.
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Zijdenbos AP, Forghani R, Evans AC. Automatic “pipeline” analysis of 3-D MRI data for clinical trials: application to multiple sclerosis. IEEE Trans Med Imaging 2002;21(10):1280-1291.
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Customized Applications

Our experts are always available to develop tools to meet your specific needs. Please do not hesitate to contact our technology team to discuss your project.

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